It's complicated, and it's constantly evolving. In general, the best way still seems to NOT have the receiver as the control center of the whole-house distribution, even though manufacturers try to make it sound like they have the perfect solution for doing that. The receiver is the control...
Multi-room is a lot more complicated than you think it is. First off, there is no way to power remote speakers through Wi-Fi. You can distribute it through Wi-Fi, but you'll need to power it in the remote rooms. Distributing audio from your TV to remote rooms will be complicated as well...