Yes, it's far more adult-oriented than kid-oriented, but TVonDVDJunkie05's master list includes the Williams Street series Harvey Birdman, Attorney at Law and Sealab 2021, also both parodies with major adult bents to them, and I noticed Space Ghost Coast-to-Coast was absent, as are Aqua Teen...
A few major things to add--
Bob Clampett Productions:
Beany & Cecil (2 volumes of 'Best of' collections of the cartoons and the live-action puppet version/Image Entertainment** and Hen's Tooth)
Disney:
Donald Duck (Disney Treasures, 4 vols of theatrical cartoons)
Goofy (Disney Treasures...