It think it's much older even than that. "Old Dark House" mysteries were already starting to become passe by 1932 and the very title is a joke making fun of that particularly well-worn trope.
Freaks (1932)? It was reissued as Nature's Mistakes but I don't think it was ever called Misfits.
If so, Tod Browning DID direct it but he did so over in Culver City at MGM